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Year : 2006  |  Volume : 8  |  Issue : 2  |  Page : 56-58

Pilot Sudy : Efficacy And Safety Of A Polyherbal Preparation (Dia-No) As An Adjuvant In Type 2 Diabetes Mellitus



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Sunil Ambhore


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Introduction : Traditional herbs from India have been tested in Diabetes for more than 200 years but classical trials in modern medicine are rare. 4 classic herbs have been combined essentially in a fibre based lifestyle approach of Dia No a polyherbal preparation containing water extracts of 500mg of Syzygium Jambolanum (500 mg), Trigonella Foenum Graceu (500 mg), Melia Azadirachta (500 mg) and Phyllanthus Emblica (625 mg). The classical cohort of Mild Obese type 2 Diabetes was enrolled for this preliminary study for efficacy and safety. Methods And Materials : 30 consecutive subjects were randomly assigned to the study group after meeting the inclusion and exclusion criteria. After approval by the ethics committee selected subjects were given strict lifestyle advice by a RD and were administered Dia-No 1 tablets before food twice a day. The auxology, metabolic profile FBG, PPBG and HBA1c as well as lipid profile was done pre and post therapy after 3 months. For safety Renal Function and Liver functions were also monitored. Results : The study group had 16 males and 14 females with mean age of 54 years. The mean weight pre therapy was 66 kg and post therapy 64 kg which was not statistically significant. The pre therapy Mean FBG =179mg%, Mean PPBG=284 mg% and Glycosylated Hb = 9.6%. The post therapy mean FBG was = 128 mg%, Mean PPBG = 180 mg% and Glycosylated Hb = 7.1% which had a p<0.001 statistically significant. The waist kinetics and lipid profile also statistically improved. Conclusion : A simple traditional 4 herb formulation of Methi, Amla, Neem and Jamun with lifestyle is effective in controlling glycemia dyslipidemia in Obese Mild Type 2 Asian Indian Diabetics.


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