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REVIEW ARTICLE
Year : 2011  |  Volume : 15  |  Issue : 8  |  Page : 317-321

Cushing's syndrome: Stepwise approach to diagnosis


Department of Endocrinology, Seth G. S. Medical College, Parel, Mumbai, Maharashtra, India

Correspondence Address:
Anurag R Lila
Department of Endocrinology, Seth G. S. Medical College, Parel, Mumbai - 400 012, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.86974

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The projected prevalence of Cushing's syndrome (CS) inclusive of subclinical cases in the adult population ranges from 0.2-2% and it may no longer be considered as an orphan disease (2-3 cases/million/year). The recognition of CS by physicians is important for early diagnosis and treatment. Late-night salivary cortisol, dexamethasone suppressiontesti, or 24-h urine free cortisol are good screening tests. Positively screened cases need stepwise evaluation by an endocrinologist. This paper discusses the importance of screening for CS and suggests a stepwise diagnostic approach to a case of suspected hypercortisolism.


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