Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Advertise | Login 
 
Search Article 
  
Advanced search 
  Users Online: 1092 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  

 
Table of Contents
LETTER TO THE EDITOR
Year : 2012  |  Volume : 16  |  Issue : 1  |  Page : 148

Authors' reply


Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Date of Web Publication26-Dec-2011

Correspondence Address:
Anil Bhansali
Department of Endocrinology, PGIMER, Chandigarh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 22276272

Rights and PermissionsRights and Permissions

How to cite this article:
Dutta P, Bhansali A, Shah V N, Walia R, Bhadada S K. Authors' reply. Indian J Endocr Metab 2012;16:148

How to cite this URL:
Dutta P, Bhansali A, Shah V N, Walia R, Bhadada S K. Authors' reply. Indian J Endocr Metab [serial online] 2012 [cited 2019 Nov 12];16:148. Available from: http://www.ijem.in/text.asp?2012/16/1/148/91216

Sir,

Thank you for taking an interest in our article. [1] The differentials like pituitary apoplexy, cyst and hypophysitis, can easily be sorted out from pituitary metastasis by symptomatology, careful clinical examination and imaging. Metastasis occurring in preexisting adenoma leading to sudden increase in size of the tumor is a diagnostic challenge; however, the pituitary metastases usually involve neurohypophysis and stalk than adenohypophysis. Diagnosis of pituitary carcinoma is based on the presence of metastasis, either intracranial, extrasellar or extracranial. [2] In the first two cases, both had histological proven adenocarcinoma and squamous cell carcinoma, and furthermore, there was no intracranial metastasis, and hence the possibility of pituitary carcinoma is unlikely. Immunohistological markers including proliferative indices and electron microscopy can substantiate the diagnosis of pituitary metastasis; however, these were not done in our study. These cases are rare and we do not think it is the referral bias. But one should have strong suspicion when systemic malignancy is associated with pituitary enlargement. Therefore, all diagnostic modalities should be employed to prove or disprove histopathologic diagnosis of pituitary metastases in a given scenario, as the prognostic significance is different when compared to other pituitary pathologies.

 
   References Top

1.Dutta P, Bhansali A, Shah VN, Walia R, Bhadada SK, Paramjeet S, et al. Pituitary metastasis as a presenting manifestation of silent systemic malignancy: A retrospective analysis of four cases. Indian J Endocrinol Metab 2011;15 Suppl 3:S242-5.   Back to cited text no. 1
[PUBMED]  [FULLTEXT]  
2.Kaltsas GA, Nomikos P, Kontogeorgos G, Buchfelder M, Grossman AB. Diagnosis and management of pituitary carcinomas. J Clin Endocrinol Metab 2005;90:3089-99.  Back to cited text no. 2
[PUBMED]  [FULLTEXT]  




 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    References

 Article Access Statistics
    Viewed911    
    Printed24    
    Emailed0    
    PDF Downloaded152    
    Comments [Add]    

Recommend this journal