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Year : 2012  |  Volume : 16  |  Issue : 2  |  Page : 214-219

Sexual and gonadal dysfunction in chronic kidney disease: Pathophysiology


Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Manish Rathi
Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh - 160012
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.93738

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Sexual and gonadal dysfunction/infertility are quite common in patients with chronic kidney disease. Forty percent of male and 55% of female dialysis patients do not achieve orgasm. The pathophysiology of gonadal dysfunction is multifactorial. It is usually a combination of psychological, physiological, and other comorbid factors. Erectile dysfunction in males is mainly due to arterial factors, venous leakage, psychological factors, neurogenic factors, endocrine factors, and drugs. Sexual dysfunction in females is mainly due to hormonal factors and manifests mainly as menstrual irregularities, amenorrhea, lack of vaginal lubrication, and failure to conceive. Treatment of gonadal dysfunction in chronic kidney disease is multipronged and an exact understanding of underlying pathology is essential in proper management of these patients.


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