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REVIEW ARTICLE
Year : 2012  |  Volume : 16  |  Issue : 2  |  Page : 220-227

Erythropoietin use and abuse


1 Department of Clinical Haematology, Haemato-Oncology and Bone Marrow Transplant Unit, Christian Medical College, Ludhiana, India
2 Department of Medicine, Christian Medical College, Ludhiana, India
3 Department of Medical Oncology Unit, Christian Medical College, Ludhiana, India
4 Department of Endocrine and Diabetes Unit, Christian Medical College, Ludhiana, India

Correspondence Address:
Jubbin J Jacob
Department of Medicine, Endocrine and Diabetes Unit, Christian Medical College, Ludhiana - 141 008, Punjab
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.93739

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Recombinant human erythropoietin (rhEPO) is arguably the most successful therapeutic application of recombinant DNA technology till date. It was isolated in 1977 and the gene decoded in 1985. Since then, it has found varied applications, especially in stimulating erythropoiesis in anemia due to chronic conditions like renal failure, myelodysplasia, infections like HIV, in prematurity, and in reducing peri-operative blood transfusions. The discovery of erythropoietin receptor (EPO-R) and its presence in non-erythroid cells has led to several areas of research. Various types of rhEPO are commercially available today with different dosage schedules and modes of delivery. Their efficacy in stimulating erythropoiesis is dose dependent and differs according to the patient's disease and nutritional status. EPO should be used carefully according to guidelines as unsolicited use can result in serious adverse effects. Because of its capacity to improve oxygenation, it has been abused by athletes participating in endurance sports and detecting this has proved to be a challenge.


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