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CASE-BASED REVIEW OF LITERATURE
Year : 2012  |  Volume : 16  |  Issue : 3  |  Page : 436-440

Dysgerminoma in a female with turner syndrome and Y chromosome material: A case-based review of literature


1 Department of Endocrinology, Medwin Hospital, Hyderabad, Andhra Pradesh, India
2 Department of Obstetrics and Gynecology, Riyadh Care Hospital, Saudi Arabia
3 Department of Obstetrics and Gynecology, Apollo Hospitals, Bhubaneswar, Orissa, India
4 Department of Anesthesia, Central Security hospital, Riyadh, Saudi Arabia
5 Department of Medicine, MKCG Medical College, Berhampur, Orissa, India

Correspondence Address:
Sunil Kumar Kota
Department of Endocrinology, Medwin Hospitals, Chiragh Ali Lane, Nampally, Hyderabad-500001, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.95706

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We report a 17-year-old girl evaluated for primary amenorrhea. Cytogenetic analysis of the peripheral blood lymphocytes revealed normal autosomes with 46X inv (Y) confirming the diagnosis of Turner's syndrome with Y cell line. Treatment was initiated with conjugated estrogen while recommending bilateral prophylactic oophorectomy to the patient. One year later the patient presented with abdominal mass, biopsy of the specimen following resection confirmed dysgerminoma originating from right ovary with no invasion or metastasis. The literature is reviewed with regard to the various pathogenetic mechanisms proposed for the development of germ cell tumors in ovary, the cytogenetic findings and recommendations to handle such scenario.


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