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LETTER TO THE EDITOR
Year : 2012  |  Volume : 16  |  Issue : 3  |  Page : 485-486

Hyperandrogenemia due to ingestion of Butea superba


1 Mahidol Nutrition Society, Mahidol University, Thailand
2 Hainan Medical University, China; Joseph AyoBabalola, Nigeria

Date of Web Publication5-May-2012

Correspondence Address:
Kamon Chaiyasit
Mahidol Nutrition Society, Mahidol University

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.95756

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How to cite this article:
Chaiyasit K, Wiwnaitkit V. Hyperandrogenemia due to ingestion of Butea superba . Indian J Endocr Metab 2012;16:485-6

How to cite this URL:
Chaiyasit K, Wiwnaitkit V. Hyperandrogenemia due to ingestion of Butea superba . Indian J Endocr Metab [serial online] 2012 [cited 2018 May 26];16:485-6. Available from: http://www.ijem.in/text.asp?2012/16/3/485/95756

Sir,

Androgen or testosterone is an important masculine hormone. It helps construct the male appearance. Hyperandrogenemia is majorly described in of females with hirsutism, [1] insulin resistance [2] and polycystic ovarian syndrome. [3] However, hyperandrogenemia in males is not frequently mentioned. In this short article, the authors report a case of hyperandrogenemia due to ingestion of Butea superba, a herb found in South East Asia. This is an interesting case of hyperandrogenemia induced by an external source. The effect of phytoandrogens is also discussed.

The patient was a Thai single male, aged 35 years, without any underlying disease (his basic annual laboratory checkup showed normal results). On presentation, the chief complaint of this patient was a feeling of increased sexual drive. He gave the history of no use of narcotic and regular intake of vitamin and nutritional supplementation. Physical examination revealed no significant abnormality. Laboratory investigations were performed which showed increased dihydrotestosterone (1512 pg/mL, reference value 250-990 pg/mL). The results of other sexual hormone related investigations in this case included dehydroepiandrosterone sulfate 328 ΅g/dL, free testosterone 1.7% and sex hormone binding globulin 43.24 nmol/L [no data on follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels]. The diagnosis of hyperandrogenemia in this case was therefore arrived at. Further investigation to find the source of androgen in this case was performed. With complete history taking, the clinical nutritionist could define an important problematic food component, B. superba, a local herb. The patient gave additional information that he had just taken this locally made capsule of this herb for a few weeks because he was suffering from hair loss. This patient was advised to stop ingestion of this herb, and follow-up after 1 week revealed that the patient had no feeling of increased sexual drive and dihydrotestosterone had decreased to normal level.

In general, androgen plays an important role in the sexual drive of males. Decreased androgen level is strongly related to reduced sexual activity and decreased sexual drive. [4] This is a common problem in old males [4] and in cases with erectile dysfunction. [5] In males with the problem of sexual desire, androgen investigation is a useful test. [6] In this case report, the patient also complained of increased sexual desire, which hmight have been due to exogenous hyperandrogenemeia.. Similar to hyperestrogenemia caused due to phytoestrogens, some herbal regimens might contain phytoandrogens that can lead to hyperandrogenemia. In this case, B. superba is the problematic external source of excessive androgen. This plant is considered to be a male potency herb. In animal models receiving this herb, stimulation of sexual organ has been reported. [7],[8] In case of human beings, there is only one previous trial using this herb for treating erectile dysfunction. [9] The effect of this herb is comparable to that of sildenafil. [9] However, there has never been any report on this herb in healthy males. This is the first case report on hyperandrogenemia due to ingestion of B. superba. With the widespread usage of local herbs presently, the effects of herbs need to be considered. Indeed, a previous report also mentioned genotoxicity due to large dosage ingestion of B. superba.[10]

 
   References Top

1.Maroulis GB. Evaluation of hirsutism and hyperandrogenemia. Fertil Steril 1981;36:273-305.  Back to cited text no. 1
    
2.Barbieri RL, Ryan KJ. Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: A common endocrinopathy with distinct pathophysiologic features. Am J Obstet Gynecol 1983;147:90-101.   Back to cited text no. 2
    
3.Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R. Polycystic ovary syndrome: Etiology, pathogenesis and diagnosis. Nat Rev Endocrinol 2011;7:219-31.  Back to cited text no. 3
    
4.Davidson JM, Chen JJ, Crapo L, Gray GD, Greenleaf WJ, Catania JA. Hormonal changes and sexual function in aging men. J Clin Endocrinol Metab 1983;57:71-7.  Back to cited text no. 4
    
5.Guay A, Jacobson J. The relationship between testosterone levels, the metabolic syndrome (by two criteria), and insulin resistance in a population of men with organic erectile dysfunction. J Sex Med 2007;4:1046-55.  Back to cited text no. 5
    
6.Corona G, Petrone L, Mannucci E, Ricca V, Balercia G, Giommi R, et al. The impotent couple: Low desire. Int J Androl 2005;28 Suppl 2:46-52.  Back to cited text no. 6
    
7.Malaivijitnond S, Ketsuwan A, Watanabe G, Taya K, Cherdshewasart W. Luteinizing hormone reduction by the male potency herb, Butea superba Roxb. Braz J Med Biol Res 2010;43:843-52.  Back to cited text no. 7
    
8.Malaivijitnond S, Ketsuwan AN, Watanabe G, Taya K, Cherdshewasart W. Androgenic activity of the Thai traditional male potency herb, Butea superba Roxb., in female rats. J Ethnopharmacol 2009;121:123-9.   Back to cited text no. 8
    
9.Cortés-González JR, Arratia-Maqueo JA, Gómez-Guerra LS, Holmberg AR. The use of Butea superba (Roxb.) compared to sildenafil for treating erectile dysfunction. BJU Int 2010;105:225-8.   Back to cited text no. 9
    
10.Cherdshewasart W, Sutjit W, Pulcharoen K, Chulasiri M. Mutagenic and antimutagenic effects of the traditional herb used for treating erectile dysfunction, Butea superba Roxb. Biosci Biotechnol Biochem 2010;74:923-7.  Back to cited text no. 10
    



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