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REVIEW ARTICLE
Year : 2012  |  Volume : 16  |  Issue : 9  |  Page : 549-555

Leptin therapy, insulin sensitivity, and glucose homeostasis


Department of Translational Medicine, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia

Correspondence Address:
Gilberto Paz-Filho
The John Curtin School of Medical Research, The Australian National University, Garran Rd, Building 131, Acton ACT, 0200
Australia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.105571

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Glucose homeostasis is closely regulated not only by insulin, but also by leptin. Both hormones act centrally, regulating food intake and adiposity in humans. Leptin has several effects on the glucose-insulin homeostasis, some of which are independent of body weight and adiposity. Those effects of leptin are determined centrally in the hypothalamus and peripherally in the pancreas, muscles and liver. Leptin has beneficial effects on the glucose-insulin metabolism, by decreasing glycemia, insulinemia and insulin resistance. The understanding of the effects of leptin on the glucose-insulin homeostasis will lead to the development of leptin-based therapies against diabetes and other insulin resistance syndromes. In these review, we summarize the interactions between leptin and insulin, and their effects on the glucose metabolism.


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