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REVIEW ARTICLE
Year : 2012  |  Volume : 16  |  Issue : 9  |  Page : 588-595

The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults


Department of Environmental Safety, Graduate School of Science and Engineering, Yamaguchi University, Japan

Correspondence Address:
Masayuki Okuda
Department of Environmental Safety, Graduate School of Science and Engineering, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube 755-8505
Japan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.105576

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Genome-wide association analyses have revealed common gene variations related to obesity. Variants of the fat mass and obesity-associated (FTO) gene among more than 40 genes studied were most closely associated with obesity, but the association varies among ethnicities. Moreover, the effect is significant in people of European descent as well as Asians, but less significant among people of African descent. Although the variants were also associated with type 2 diabetes and glucose homeostasis, the associations were attenuated or abolished after adjusting for adiposity. The present review considers our current understanding of the effects of the FTO variants in different ethnic groups and in adults and children.


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