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REVIEW ARTICLE
Year : 2012  |  Volume : 16  |  Issue : 9  |  Page : 596-600

Leptin and cancer: Pathogenesis and modulation


Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research Kolkata, Kolkata, India

Correspondence Address:
Sujoy Ghosh
Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research Kolkata, 244 AJC Bose Road, Kolkata-700 020
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.105577

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Leptin, a product of Ob gene from adipocytes regulates appetite, energy expenditure and body mass composition by decreasing orexigenic and increasing anorexigenic neuropeptide release from hypothalamus. Research over the past few years have suggested leptin/leptin receptor dysregulation to have a role in the development of a large variety of malignancies like breast ca, thyroid ca, endometrial ca and gastrointestinal malignancies, predominantly through JAK/STAT pathway which modulates PI3K/AKT3 signaling, ERK1/2 signaling, expression of antiapoptotic proteins (like XIAP), systemic inflammation (TNF-α, IL6), angiogenic factors (VEGF) and hypoxia inducible factor-1a (HIF-1a) expression. In this review, the current understanding of leptin's role in carcinogenesis has been elaborated. Also a few agents modulating leptin signaling to inhibit cancer cell growth has been described.


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