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REVIEW ARTICLE
Year : 2012  |  Volume : 16  |  Issue : 9  |  Page : 627-636

PVN pathways controlling energy homeostasis


Department of Physiology and Pharmacology, Center for Diabetes and Endocrine Research, University of Toledo Medical Center, Obstetrics-Gynecology, University of Toledo, USA

Correspondence Address:
Jennifer W Hill
University of Toledo College of Medicine, Mail Stop 1008, 3000 Transverse Avenue, Toledo, OH 43614
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.105581

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Research into the control of energy balance has tended to focus on discrete brain regions, such as the brainstem, medulla, arcuate nucleus of the hypothalamus, and neocortex. Recently, a larger picture has begun to emerge in which the coordinated communication between these areas is proving to be critical to appropriate regulation of metabolism. By serving as a center for such communication, the paraventricular nucleus of the hypothalamus (PVH) is perhaps the most important brain nucleus regulating the physiological response to energetic challenges. Here we review recent advances in the understanding of the circuitry and function of the PVH.


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