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REVIEW ARTICLE
Year : 2012  |  Volume : 16  |  Issue : 9  |  Page : 637-643

Benefits of leptin therapy in HIV patients


1 Department of Medicine, Nilratan Sircar Medical College, Kolkata, India
2 Department of Endocrinology, Nilratan Sircar Medical College, Kolkata, India

Correspondence Address:
Uma Sinha
Department of Medicine, Nilratan Sircar Medical College and Hospital, 138 A. J. C. Bose Road, 19/1C, Sil Lane, Entally, Kolkata - 15, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.105583

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Leptin therapy in human recombinant form has recently been used in HIV-associated lipodystrophy syndrome on experimental basis in some small short-term clinical trials. It has shown its beneficial effects only in hypoleptinemic HIV-infected patients by causing definite improvement in their insulin sensitivity, glucose tolerance, lipid status, and truncal obesity. Leptin prevents lipotoxicity and activates insulin signaling pathways through several postulated mechanisms. Central leptin insufficiency with peripheral hyperleptinemia has come out to be a significant contributor to the development of obesity and metabolic syndrome. In this article, we will review the basis of leptin therapy in HIV patients, with its promises. However, further larger clinical trials are needed to prove its long-term efficacy in the control of metabolic complications related to HIV therapy.


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