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REVIEW ARTICLE
Year : 2014  |  Volume : 18  |  Issue : 3  |  Page : 283-287

Role of Glitazars in atherogenic dyslipidemia and diabetes: Two birds with one stone?


1 Consultant Endocrinologist, Fortis Hospital, Bangalore, Karnataka, India
2 Director, Institute of Endocrinology, Diabetes and Osteoporosis, Sakra World Hospitals, Marathahalli, Bangalore, Karnataka, India

Correspondence Address:
Srinivasa P Munigoti
Consultant Endocrinologist, Fortis Hospital, Bannerghatta Road, Bangalore, Karnataka - 560 072
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.131134

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A triad of high triglycerides, low high-density lipoprotein (HDL) cholesterol, and elevated small dense low-density lipoprotein particles occurring in a patient with type 2 diabetes is referred to atherogenic diabetic dyslipidemia (ADD). Despite statin therapy, a significant residual risk remains potentially attributable to increased triglyceride concentration and low HDL cholesterol, a characteristic hallmark of ADD. Current therapeutic options in reducing this residual risk include nicotinic acid, omega 3 fatty acids, and selective peroxisome proliferator-activated receptor-alpha (PPAR) agonists (fibrates). These drugs are limited in their potential either by lack of evidence to support their role in reducing cardiovascular events or due to their side effects. This review details their current status and also the role of new glitazar, saroglitazar adual PPARα/γ agonist with predominant PPARα activity in the management of ADD.


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