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ORIGINAL ARTICLE
Year : 2014  |  Volume : 18  |  Issue : 4  |  Page : 491-495

Efficacy of insulin lispro in improving glycemic control in gestational diabetes


1 Diabetologist, Madhav Diabetes Centre, Anna Nagar, Chennai, India
2 Cons. Obstetrician and Gynaecology, Joseph Nursing Home, Chennai, India
3 Dr. Nandita's Fertility Centre, Chetput, Chennai, India

Correspondence Address:
M C Deepaklal
Diabetologist Madhav Diabetes Centre, Anna Nagar, Chennai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.137492

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Aim: To assess the safety and efficacy of insulin lispro in improving glycemic control in patients with gestational diabetes. Materials and Methods: A retrospective observational study was conducted at a single center on 201 gestational women with diabetes. Subjects who received insulin lispro performed blood glucose self-monitoring and recorded the readings in the fasting state and 1 h after each meal. At each contact (in person or telephonic contact), the insulin dose was adjusted based on the readings measured. A total of 53 subjects also recorded glucose levels post-partum. Pregnancy and post-delivery glucose level and insulin requirements of these 53 patients were compared. Results: Analysis of glucose levels both fasting and post-prandial glucose levels revealed that after using insulin lispro, the number of episodes of post-prandial hyperglycemia (1 h plasma glucose >120 mg/dL) was minimal and so was the incidence of hypoglycemia. Hypoglycemia was defined as a blood sugar value of. There was neither any congenital abnormality except for a poorly formed pinna in the right ear of one baby nor any post-partum complications of note. Conclusion: Insulin lispro is an effective and safe treatment option in gestational diabetes.


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