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ORIGINAL ARTICLE
Year : 2015  |  Volume : 19  |  Issue : 1  |  Page : 124-128

Evaluation of glutathione S-transferase T1 deletion polymorphism on type 2 diabetes mellitus risk in Zoroastrian females in Yazd, Iran


1 Medical Scientific Association, Ali-Ebne Abitaleb Faculty of Medicine, Islamic Azad University, Yazd Branch, Iran
2 Department of Endocrinology, Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3 Department of Biostatistics and Epidemiology, Ali-Ebne Abitaleb Faculty of Medicine, Islamic Azad University, Yazd Branch, Iran
4 Department of Medical Genetics, Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Correspondence Address:
Mohammadhosain Afrand
Medical Scientific Association, Islamic Azad University, Safaiyeh Boulevard Daneshgah, Ali-Ebne Abitaleb Faculty of Medicine, Yazd 8917145438
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.146867

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Background: There has been much interest in the role of free radicals and oxidative stress in the pathogenesis of diabetes mellitus (DM). The aim of this study was to assess the possible association between genetic polymorphisms of the glutathione S-transferase-Theta (GSTT1) and the risk of the development of DM in Zoroastrian females in Yazd, Iran. Materials and Methods: This was a case-control study in which GSTT1 polymorphism was genotyped in 51 randomly selected DM patients and 50 randomly selected healthy controls among Zoroastrian females whose ages ranged from 40 to 70. Results: The frequencies of GSTT1 null genotype and GSTT1 present were 72% and 28%, respectively, in control samples, while in patients with type 2 diabetes (T2DM), the frequencies of GSTT1 null genotype and GSTT1 present were 27.5% and 72.5%, respectively. There were higher levels of triglyceride (TG), fasting blood sugar (FBS), total cholesterol (TC), low-density lipoprotein (LDL), Urea, and high-density lipoprotein (HDL) in cases of GSTT1 null genotype compared to the GSTT1 present genotype in controls. Conclusions: Our results indicated that healthy subjects had a higher frequency of the GSTT1 null genotype than patients with T2DM. However, we observed no significant association between the GSTT1 null genotype and T2DM in the current study.


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