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BRIEF COMMUNICATION
Year : 2015  |  Volume : 19  |  Issue : 1  |  Page : 155-159

Maternal serum biomarkers for risk assessment in gestational diabetes. A potential universal screening test to predict GDM status


1 DiabetOmics Inc, Beaverton, Oregon, USA
2 Oregon Health and Science University, Portland, Oregon, USA
3 Dr. V. Seshiah Diabetes Care and Research Institute, Chennai, Tamil Nadu, USA
4 Department of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences University, Hyderabad, Telangana, India

Correspondence Address:
Paturi V Rao
Department of Endocrinology and Metabolism, Nizamís Institute of Medical Sciences University, Hyderabad - 500 082, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.140226

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The prevalence of gestational diabetes mellitus (GDM) is increasing because of the worldwide obesity/diabetes epidemic. The complications of untreated GDM affect both the mother and baby and include complications during pregnancy as well as increased risk of subsequent type-2 diabetes in mothers and offspring. Standard tests for hyperglycemia in diabetes, such as fasting glucose and hemoglobin (HbA1c), are currently not recommended for GDM screening. Instead, an oral glucose tolerance test is specified, which is invasive, time-consuming, and not easily accessible to many at-risk populations. In this study, we describe a multi-analyte maternal serum profile test that incorporates novel glycoprotein biomarkers and previously described GDM-associated markers. In screening for GDM by multi-analyte panel, the detection rate was 87% at a false-positive rate of 1%.


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