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ORIGINAL ARTICLE
Year : 2015  |  Volume : 19  |  Issue : 1  |  Page : 77-83

Impact of the Pro12Ala polymorphism of the PPARγ2 gene on diabetes and obesity in a highly consanguineous population


1 Department of Medical Statistics and Epidemiology, Hamad Medical Corporation, Doha, Qatar; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, The University of Manchester, Manchester, UK
2 Department of Endocrinology, Hamad Medical Corporation, Hamad General Hospital, Qatar
3 Qatar Diabetic Association and Qatar Foundation, Doha, Qatar
4 Department of Laboratory Medicine and Pathology, Cytogenetics and Molecular Cytogenetics Laboratory, Hamad Medical Corporation, Qatar
5 Department of Medical Statistics and Epidemiology, Hamad Medical Corporation, Doha, Qatar
6 Department of Oncology, Wayne State University, School of medicine, Michigan, USA, and Department of Medicine, Hamad Medical Corporation, State of Qatar

Correspondence Address:
Abdulbari Bener
Departments of Medical Statistics and Epidemiology, Hamad Medical Corporation and Department of Public Health, Weill Cornell Medical College, PO Box 3050, Doha, State of Qatar

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.131766

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Background: The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor subfamily of transcription factors. It has been reported that they play important roles in obesity and the development of type 2 diabetes mellitus (T2DM). Materials and Methods: This case-control study was carried out among 764 Qatari patients with diabetes and 764 healthy subjects above 20 years of age at Primary Healthcare Clinics (PHCs) from January 2011 to December 2012. Face-to-face interviews were based on a questionnaire that included variables such as age, sex, sociodemographic status, body mass index (BMI) and other clinical parameters. The Pro12Ala in the PPARγ2 gene was detected on the LightCycler using two specific probes. Univariate and multivariate statistical analysis were performed. Results: The study revealed that in the diabetes group, Pro/(10.2% vs 9.4%; P = 0.606) and Ala/Ala (1.4% vs 0.9%; P = 0.343) were higher than in controls, whereas Pro/Pro (88.4% vs 89.7%;P = 0.413) was lower in diabetes patients, but no significant difference was observed among the genotype groups. In obese patients with diabetes, Pro/Pro (89% vs 89.9%;P = 0.792) and Pro/Ala (8.9% vs 10.1%;P = 0.671) were lower than in obese healthy subjects. No homozygous Ala/Ala was found in obese healthy subjects, whereas 6 Ala/Ala homozygotes were in obese diabetes group. But in diabetes group, obese patients had higher homozygous of Pro/Pro (89.3% vs 87.8%;P = 0.523) and Ala/Ala (1.8% vs 1.2%;P = 0.771) compared to non-obese patients. Conclusion: The current study did not reveal an association between the Pro12Ala polymorphism of the PPAR γ2 gene and type 2 diabetes (T2D) in Qatari's population.


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