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ORIGINAL ARTICLE
Year : 2015  |  Volume : 19  |  Issue : 2  |  Page : 277-282

Metabolic syndrome: An independent risk factor for erectile dysfunction


1 Department of Endocrinology, LLRM Medical College, Meerut, India
2 Department of Biochemistry, Subharti Medical College, Meerut, India
3 Department of Endocrinology, Pushpagiri Medical College Thiruvalla, Kerala, India
4 Department of Endocrinology, Hormone Care and Research Centre, Ghaziabad, Uttar Pradesh, India
5 Department of Ophthalmology, Subharti Medical College, Meerut, India

Correspondence Address:
Saran Sanjay
3B Dwarika Towers, Opp. LLRM Medical College, Meerut - 250 004, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.149322

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Objective: The objective was to determine the role of various components of metabolic syndrome (MetS) as independent risk factor for erectile dysfunction (ED). Materials and Methods: A total of 113 subjects of MetS, as recommended by recent IDF and AHA/NHLBI joint interim statement were selected for study who presented for ED. After doing Anthropometric examination, fasting laboratory assay for fasting plasma glucose (FPG), fasting insulin, hemoglobin A1c, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and 2 h oral glucose tolerance test (OGTT) was done. Erectile function was assessed by completing questions one through five of the International Index of Erectile Function (IIEF-5). A multiple linear regression analysis was carried out on 66 subjects with IIEF-5 score as dependent variable and components of MetS FPG, 2 h OGTT, TG, HDL, and waist circumference as independent variables. Results: Using a multiple linear regression analysis, we observed that presence of the various components of MetS was associated with ED and a decrease IIEF-5 score and this effect was greater than the effect associated with any of the individual components. Of the individual components of the MetS, HDL (B = 0.136; P = 0.004) and FPG (B = −0.069; P = 0.007) conferred the strongest effect on IIEF-5 score. However, overall age had most significant effect on IIEF-5 score. Conclusion: It is crucial to formulate strategies and implement them to prevent or control the epidemic of the MetS and its consequences. The early identification and treatment of risk factors might be helpful to prevent ED and secondary cardiovascular disease, including diet and lifestyle interventions.


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