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BRIEF COMMUNICATION
Year : 2016  |  Volume : 20  |  Issue : 5  |  Page : 725-729

Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect


1 Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India
2 Department of Medicine, Boehringer Ingelheim India Pvt, Ltd., Delhi, India
3 Department of Medicine, Boehringer Ingelheim Pvt Ltd, Mumbai, Maharashtra, India
4 Chellaram Diabetes Institute, Pune, Maharashtra, India

Correspondence Address:
Sanjay Kalra
Department of Endocrinology, Bharti Hospital, Karnal, Haryana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.183826

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This review discusses two distinct, yet related, mechanisms of sodium-glucose cotransporter 2 (SGLT2) inhibition: Calorie restriction mimicry (CRM) and pro-ketogenic effect, which may explain their cardiovascular benefits. We term these adaptive CRM and pro-ketogenic effects of SGLT2 inhibition, the Robin Hood hypothesis. In English history, Robin Hood was a "good person," who stole from the rich and helped the poor. He supported redistribution of resources as he deemed fit for the common good. In a similar fashion, SGLT2 inhibition provides respite to the overloaded glucose metabolism while utilizing lipid stores for energy production.


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