Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Advertise | Login 
 
Search Article 
  
Advanced search 
  Users Online: 2839 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  
ORIGINAL ARTICLE
Year : 2017  |  Volume : 21  |  Issue : 4  |  Page : 551-554

Increased levels of serum interleukin-17 in patients with Hashimoto's thyroiditis


1 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences; Department of Endocrinology, Imam Khomeini General Hospital, Tehran, Iran
2 Department of Endocrinology, Imam Khomeini General Hospital, Tehran, Iran
3 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Zohreh Jadali
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, P. O. Box 6446, Tehran 14155
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijem.IJEM_412_16

Rights and Permissions

Background: CD4+ T-cells play important roles in the pathogenesis of Hashimoto's thyroiditis (HT). However, there is limited data about characteristics and function of the newly interleukin (IL)-17–producing T-helper cells in this common autoimmune thyroid disorder. Aim: The purpose of this study was to assess the levels of T-helper 17-related cytokines in sera of patients with HT. Materials and Methods: Cytokine concentrations were measured in 48 patients with overt (n = 23) and subclinical hypothyroidism (25) and 35 healthy controls using enzyme-linked immunosorbent assay. Results: The serum levels of IL-17 were significantly higher in patients than controls (P = 0.001) while no differences were observed with regard to levels of IL-22 and IL-23 between patients and normal controls. Conclusion: These results suggest that IL-17 could play some role in the pathogenesis of HT.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed939    
    Printed12    
    Emailed0    
    PDF Downloaded242    
    Comments [Add]    
    Cited by others 4    

Recommend this journal