Indian Journal of Endocrinology and Metabolism

: 2012  |  Volume : 16  |  Issue : 2  |  Page : 204--213

Interactions between thyroid disorders and kidney disease

Gopal Basu, Anjali Mohapatra 
 Department of Nephrology, Christian Medical College, Vellore, Tamil Nadu, India

Correspondence Address:
Gopal Basu
Department of Nephrology, Christian Medical College, Vellore - 632004, Tamil Nadu

There are several interactions between thyroid and kidney functions in each other organ«SQ»s disease states. Thyroid hormones affect renal development and physiology. Thyroid hormones have pre-renal and intrinsic renal effects by which they increase the renal blood flow and the glomerular filtration rate (GFR). Hypothyroidism is associated with reduced GFR and hyperthyroidism results in increased GFR as well as increased renin - angiotensin - aldosterone activation. Chronic kidney disease (CKD) is characterized by a low T3 syndrome which is now considered a part of an atypical nonthyroidal illness. CKD patients also have increased incidence of primary hypothyroidism and subclinical hypothyroidism. The physiological benefits of a hypothyroid state in CKD, and the risk of CKD progression with hyperthyroidism emphasize on a conservative approach in the treatment of thyroid hormone abnormalities in CKD. Thyroid dysfunction is also associated with glomerulonephritis often by a common autoimmune etiology. Several drugs could affect both thyroid and kidney functions. There are few described interactions between thyroid and renal malignancies. A detailed knowledge of all these interactions is important for both the nephrologists and endocrinologists for optimal management of the patient.

How to cite this article:
Basu G, Mohapatra A. Interactions between thyroid disorders and kidney disease.Indian J Endocr Metab 2012;16:204-213

How to cite this URL:
Basu G, Mohapatra A. Interactions between thyroid disorders and kidney disease. Indian J Endocr Metab [serial online] 2012 [cited 2020 Jul 7 ];16:204-213
Available from:;year=2012;volume=16;issue=2;spage=204;epage=213;aulast=Basu;type=0