Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 17  |  Issue : 2  |  Page : 285--288

Low triiodothyronine predicts mortality in critically ill patients


K. V. S. Hari Kumar1, Umesh Kapoor2, Richa Kalia1, N. S. Ajai Chandra3, Parikshit Singh3, R Nangia2 
1 Department of Endocrinology, Command Hospital, Lucknow Cantt, Lucknow, Uttar Pradesh, India
2 Department of Pathology, Command Hospital, Lucknow Cantt, Lucknow, Uttar Pradesh, India
3 Department of Critical Care, Command Hospital, Lucknow Cantt, Lucknow, Uttar Pradesh, India

Correspondence Address:
K. V. S. Hari Kumar
Department of Endocrinology, Command Hospital, Lucknow - 226002.UP
India

Objective: Alteration in thyroid hormones are seen in critically ill patients admitted to intensive care units. Our objective was to study the thyroid hormone profile, prolactin and, glycosylated hemoglobin (HbA1c) at admission and analyze their correlation with mortality. Materials and Methods: In this single centre, prospective, observational study, 100 consecutive patients (52M; 48F) admitted to medical ICU irrespective of diagnosis were included. Patients with previous thyroid disorders and drugs affecting thyroid function were excluded. All participants underwent complete physical examination and a single fasting blood sample obtained at admission was analyzed for total triiodothyronine (T3), total thyroxine (T4), thyroid stimulating hormone (TSH), HbA1c, and prolactin. The patients were divided into two groups: Group 1 - survivors (discharged from the hospital) and Group 2 - nonsurvivors (patients succumbed to their illness inside the hospital). The data were analyzed by appropriate statistical methods and a P-value of <0.05 was considered significant. Results: The mean age of the participants was 58.7 ± 16.9 years and the mean duration of ICU stay was 3.3 ± 3.1 days. A total of 64 patients survived, whereas remaining 36 succumbed to their illness. The baseline demographic profile was comparable between survivors and nonsurvivors. Nonsurvivors had low T3 when compared with survivors (49.1 ± 32.7 vs. 66.2 ± 30.1, P = 0.0044). There was no significant difference observed between survivors and nonsurvivors with respect to T4, TSH, HbA1c, and prolactin. Conclusion: Our study showed that low T3 is an important marker of mortality in critically ill patients. Admission HbA1c, prolactin, T4, and TSH did not vary between survivors and nonsurvivors.


How to cite this article:
Kumar KH, Kapoor U, Kalia R, Chandra NA, Singh P, Nangia R. Low triiodothyronine predicts mortality in critically ill patients.Indian J Endocr Metab 2013;17:285-288


How to cite this URL:
Kumar KH, Kapoor U, Kalia R, Chandra NA, Singh P, Nangia R. Low triiodothyronine predicts mortality in critically ill patients. Indian J Endocr Metab [serial online] 2013 [cited 2020 Aug 9 ];17:285-288
Available from: http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=2;spage=285;epage=288;aulast=Kumar;type=0