Indian Journal of Endocrinology and Metabolism

LETTER TO THE EDITOR
Year
: 2013  |  Volume : 17  |  Issue : 3  |  Page : 535--536

Utility of single photon emission computed tomography/CT hybrid imaging over planar I-131 whole body scans in detection of adrenal metastases in differentiated thyroid cancer


Nishikant Damle, Chandrasekhar Bal, Sachin Jain, Ajiv Mishra, Tarun Jain 
 Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Nishikant Damle
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi - 110 029
India




How to cite this article:
Damle N, Bal C, Jain S, Mishra A, Jain T. Utility of single photon emission computed tomography/CT hybrid imaging over planar I-131 whole body scans in detection of adrenal metastases in differentiated thyroid cancer.Indian J Endocr Metab 2013;17:535-536


How to cite this URL:
Damle N, Bal C, Jain S, Mishra A, Jain T. Utility of single photon emission computed tomography/CT hybrid imaging over planar I-131 whole body scans in detection of adrenal metastases in differentiated thyroid cancer. Indian J Endocr Metab [serial online] 2013 [cited 2020 Sep 29 ];17:535-536
Available from: http://www.ijem.in/text.asp?2013/17/3/535/111690


Full Text

Sir,

Distant metastases to the lung and bones occur in about 10% of patients with differentiated thyroid cancer (DTC), who can still survive for many years.Other sites are less frequently seen. We report here the case of a 37 year old female who presented with multiple bilateral cervical lymphadenopathy, diagnosed as metastatic papillary thyroid cancer (PTC) on cytology. She underwent total thyroidectomy, bilateral radical neck dissection followed by radioiodine therapy. During the course of successive radioiodine therapy over six years, she developed lung and bone metastases. On the 7 th post-radioiodine therapy scan, she showed a focus of radioiodine uptake in the right upper abdominal region, better seen on posterior than on anterior images. This lesion was thought to be either in the adrenals or in the ribs posteriorly [Figure 1].{Figure 1}

We did a SPECT/CT for this patient, which clearly localized the intense, focal uptake in the right adrenal gland [Figure 2]. The patient had received 1200mCi131I thus far. She was planned for another high dose therapy in view of non-availability of any other treatment in cases of disseminated thyroid cancer.{Figure 2}

Adrenal metastasis from DTC is very rare. It is generally asymptomatic and is often associated with lung or bone metastases, as in our case. Functioning adrenal metastases was first described by Koutkia and Safer. Very few cases have been reported in till now. [1],[2],[3] Even if the metastatic lesions concentrate radioiodine, this uptake is generally missed out because of the normal physiological uptake/excretion of radio iodine in the kidney and gut or since the lesion appears as if it is in the overlying rib.

So two important points that can be learnt from this case are: Firstly, patients with differentiated thyroid cancer may have asymptomatic involvement of the adrenal glands. Secondly SPECT/CT is very important for those lesions which are either doubtful or abnormal in location in planar whole body images.

References

1Koutkia P, Safer JD. Adrenal metastasis secondary to papillary thyroid carcinoma. Thyroid 2001;11:1077-9.
2Kumar A, Nadig M, Patra V, Srivastava DN, Verma K, Bal CS. Adrenal and renal metastases from follicular thyroid cancer. Br J Radiol 2005;78:1038-41.
3Malhotra G, Upadhye TS, Sridhar E, Asopa RV, Garde PS, Gawde S, et al. Unusual case of adrenal and renal metastases from papillary carcinoma of thyroid. Clin Nucl Med 2010;35:731-6.