Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 20  |  Issue : 3  |  Page : 337--342

Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome


Shahnaz Ahmad Mir1, Shariq Rashid Masoodi2, Shafia Shafi3, Iqra Hameed4, Maqsood Ahmad Dar2, Mir Iftikhar Bashir2, Arshad Iqbal Wani2, Zaffar Amin Shah5, Shameema Parveen6, Abdul Hamid Zargar2, Parviz Ahmad Shah1 
1 Division of Internal Medicine and Endocrinology, Government Medical College, Srinagar, Jammu and Kashmir, India
2 Department of Endocrinology and Metabolism, Sheri-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
3 Department of Gynaecology and Obstetrics, Government Lal Ded Hospital, Srinagar, Jammu and Kashmir, India
4 Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India
5 Department of Immunology and Molecular Medicine, Sheri-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
6 Department of Gynaecology and Obstetrics, Sheri-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India

Correspondence Address:
Shariq Rashid Masoodi
Department of Endocrinology and Metabolism, Sheri-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir
India

Introduction: Pregnant women represent a typical group susceptible to dietary and mineral deficiencies. This study was sought to assess the efficacy and safety of various doses of 25-hydroxyvitamin D (25[OH]D) supplementation during pregnancy and ratify the inadequacy of the recommended daily allowance for Vitamin D in vulnerable groups. Materials and Methods: A total of 100 pregnant women were included in this open-label, parallel group, prospective, randomized, and controlled trial. Study subjects were assigned to four treatment groups: Group 1 (n = 26), 1000 IU of Vitamin D daily; Group 2 (n = 21), 30,000 IU of Vitamin D monthly; Group 3 (n = 27), 2000 IU of Vitamin D daily; and Group 4 (n = 26), 60,000 IU Vitamin D monthly. Group 1 and 2 were further analyzed together as Group 1K (1000 IU daily and 30,000 IU monthly), and Group 3 and 4 as Group 2K (2000 IU daily and 60,000 IU monthly). The analysis was done on an intention to treat basis. Results: A total of 87 patients completed the study; 21 in Group 1, 25 in Group 2, 18 in Group 3, and 23 in Group 4. The levels of 25(OH)D at baseline ranged from 1.3 to 58.0 with a mean of 24.2 ± 15.1 ng/ml. Postsupplementation, 25(OH)D levels ranged from 11.5 to 70.3 with a mean of 40.2 ± 12.2 ng/ml. The postsupplementation levels of 25(OH)D were higher in Group 2K (42.86 ± 12.83) than in Group 1K (36.96 ± 10.56) with P value of 0.023. Conclusion: We concluded that Vitamin D supplementation with 2000 IU/day or 60,000 IU/month is very effective and safe in achieving Vitamin D sufficiency in pregnant women.


How to cite this article:
Mir SA, Masoodi SR, Shafi S, Hameed I, Dar MA, Bashir MI, Wani AI, Shah ZA, Parveen S, Zargar AH, Shah PA. Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome.Indian J Endocr Metab 2016;20:337-342


How to cite this URL:
Mir SA, Masoodi SR, Shafi S, Hameed I, Dar MA, Bashir MI, Wani AI, Shah ZA, Parveen S, Zargar AH, Shah PA. Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome. Indian J Endocr Metab [serial online] 2016 [cited 2019 Dec 12 ];20:337-342
Available from: http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=3;spage=337;epage=342;aulast=Mir;type=0