Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 20  |  Issue : 5  |  Page : 656--661

High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk


Stephen R James1, Lopamudra Ray1, Kandasamy Ravichandran2, Sunil Kumar Nanda1 
1 Department of Biochemistry, Pondicherry Institute of Medical Sciences, Puducherry, India
2 Department of Biostatistics, Pondicherry Institute of Medical Sciences, Puducherry, India

Correspondence Address:
Lopamudra Ray
Department of Biochemistry, Pondicherry Institute of Medical Sciences, Puducherry - 605 014
India

Background: A controversy exists regarding the association between subclinical hypothyroidism (SH) and dyslipidemia. Moreover, studies on lipid ratios and atherogenic index of plasma (AIP) in SH are rare, particularly in the Indian scenario. Aim: This study aimed to investigate abnormalities in conventional lipid profile, lipid ratios, and AIP in SH and attempted to correlate thyroid stimulating hormone (TSH) and AIP in SH. Materials and Methods: In this retrospective analysis of patient records of SH subjects and euthyroid subjects, age, free triiodothyronine, free thyroxine, TSH, total cholesterol, triglycerides, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol, lipid ratios, and AIP were compared between the two groups. The correlation of TSH and AIP in SH was studied. Spearman«SQ»s correlation, Mann-Whitney U-test and logistic regression analysis were performed. Results: Triglyceride, triglyceride/HDL-C, and AIP were significantly higher in SH as compared to euthyroid group, but there was no correlation between TSH and AIP in SH. AIP emerged as the significant single factor associated with SH in multiple logistic regressions. Conclusion: The positive association of dyslipidemia and SH indicates a need for regular screening of these patients to enable early diagnosis and treatment of dyslipidemia. Even in patients who have a normal conventional lipid profile, lipid ratios, and AIP have to be calculated for better assessment of atherogenic risk.


How to cite this article:
James SR, Ray L, Ravichandran K, Nanda SK. High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk.Indian J Endocr Metab 2016;20:656-661


How to cite this URL:
James SR, Ray L, Ravichandran K, Nanda SK. High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk. Indian J Endocr Metab [serial online] 2016 [cited 2020 Jul 10 ];20:656-661
Available from: http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=5;spage=656;epage=661;aulast=James;type=0