Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 22  |  Issue : 6  |  Page : 757--759

FRAX first – Pragmatic approach in resource poor settings


Adlyne Reena Asirvatham1, Karthik Balachandran1, Subramanian Kannan2, Satish K Balasubramaniam1, Shriraam Mahadevan1 
1 Department of Endocrinology, Diabetes and Metabolism, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India
2 Department of Endocrinology, Mazumdar Shaw Medical Centre, Narayana Health, Bengaluru, Karnataka, India

Correspondence Address:
Shriraam Mahadevan
Department of Endocrinology, Diabetes and Metabolism, Sri Ramachandra Medical College and Research Institute, Porur, Chennai - 600 116, Tamil Nadu
India

Background: Fracture Risk Assessment Tool (FRAX) is a fracture prediction tool that uses clinical risk factors with or without bone mineral density (BMD). BMD is difficult to obtain in resource-limited setting. Hence, we aimed to compare fracture risk prediction by FRAX without BMD (FRAX) and FRAX with BMD (FRAX/BMD). Objective: We intended to determine if FRAX and FRAX/BMD would produce identical predictions for 10-year probability of hip fracture and major osteoporotic fracture (MOF). We also desired to study the risk factors that could help to identify the similarity of risk prediction. Materials and Methods: A retrospective review of patients who underwent BMD measurement and FRAX assessment was conducted. Men and women >50 years of age with osteopenia and osteoporosis according to the World Health Organization (WHO) definition at one or more sites were included. FRAX prediction scores were calculated with and without BMD using the FRAX India tool. Results: Of 239 subjects, 207 (86.61%) had identical fracture risk predictions with or without BMD in FRAX estimation. Mean age was lower (P = 0.009), whereas body mass index (BMI), hip BMD, spine BMD, and history of previous fracture were higher (P = 0.005, P < 0.001, P < 0.001, and P = 0.02, respectively) in the identical prediction group. Conclusion: In our study, FRAX provided fracture risk prediction alike FRAX/BMD in most of the cases. FRAX is a good predictor of fractures especially in younger patients with higher BMI. Therefore, we conclude that FRAX is an effective tool to predict osteoporotic fracture risk and would be an inexpensive alternative when access to dual-energy X-ray absorptiometry (DXA) is limited.


How to cite this article:
Asirvatham AR, Balachandran K, Kannan S, Balasubramaniam SK, Mahadevan S. FRAX first – Pragmatic approach in resource poor settings.Indian J Endocr Metab 2018;22:757-759


How to cite this URL:
Asirvatham AR, Balachandran K, Kannan S, Balasubramaniam SK, Mahadevan S. FRAX first – Pragmatic approach in resource poor settings. Indian J Endocr Metab [serial online] 2018 [cited 2019 Oct 23 ];22:757-759
Available from: http://www.ijem.in/article.asp?issn=2230-8210;year=2018;volume=22;issue=6;spage=757;epage=759;aulast=Asirvatham;type=0