Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 24  |  Issue : 2  |  Page : 137--142

Parathyroid carcinoma—An experience of the enigma over 10 years


Supreet Singh Nayyar1, Shivakumar Thiagarajan1, Devendra Chaukar1, Sarbani Ghosh Laskar2, Asawari Patil3, Abhishek Mahajan4, Snehal Shah1 
1 Department of Head and Neck Surgical Oncology, Homi Bhabha National Institute, Tata Memorial Hospital, Mumbai, Maharashtra, India
2 Department of Radiation Oncology, Homi Bhabha National Institute, Tata Memorial Hospital, Mumbai, Maharashtra, India
3 Department of Pathology, Homi Bhabha National Institute, Tata Memorial Hospital, Mumbai, Maharashtra, India
4 Department of Radiology, Homi Bhabha National Institute, Tata Memorial Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Shivakumar Thiagarajan
Department of Head and Neck Surgical Oncology, Homi Bhabha National Institute, Tata Memorial Hospital, Parel, Mumbai - 400 012, Maharashtra
India

Introduction: Parathyroid carcinoma (PC) is an uncommon clinical entity. Identification and appropriate treatment of PC remains a challenge. In this study, we explore clinico-radiological features suggestive of PC, the utility of Castleman's histopathological criteria for the diagnosis of PC and discuss the MD-Anderson prognostic stratification system for PC. Methods: Retrospective analysis (case series) of patients who were treated at our tertiary oncology institution between January 2009 and December 2018 with an eventual diagnosis of PC. Results: The study group comprised 15 patients. The most common presentation was related to the musculoskeletal system (n = 9, 60%). In one of the cases, ultrasound features were recorded to be suspicious of PC. The highest histopathological correlation with PC was found with capsular and vascular invasion (n = 12, 80%). The primary tumor was found in inferior parathyroid glands in most cases (n = 12, 80%). The average tumor size was 2.47 cm. Six patients (40%) received adjuvant radiotherapy (RT). Three patients (20%) developed recurrence, all having distant metastasis. Overall survival (OS) at 3 years was 92.31% and disease-free survival (DFS) of 76.61%. Conclusion: The presence of certain features on ultrasonography might suggest PC preoperatively. Among Castleman's criteria, capsular invasion and vascular invasion had a maximum association with PC in our series. At present, there is no evidence to routinely give adjuvant RT to all patients with PC.


How to cite this article:
Nayyar SS, Thiagarajan S, Chaukar D, Laskar SG, Patil A, Mahajan A, Shah S. Parathyroid carcinoma—An experience of the enigma over 10 years.Indian J Endocr Metab 2020;24:137-142


How to cite this URL:
Nayyar SS, Thiagarajan S, Chaukar D, Laskar SG, Patil A, Mahajan A, Shah S. Parathyroid carcinoma—An experience of the enigma over 10 years. Indian J Endocr Metab [serial online] 2020 [cited 2020 Jun 3 ];24:137-142
Available from: http://www.ijem.in/article.asp?issn=2230-8210;year=2020;volume=24;issue=2;spage=137;epage=142;aulast=Nayyar;type=0