Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 24  |  Issue : 4  |  Page : 312--318

To compare the level of cystatin C in type 2 diabetes mellitus with obesity


Chahat Jhatta, Jashan Girdhar, Sumeet Gupta, Inderjeet Verma 
 Department of Pharmacy Practice, MM College of Pharmacy, Maharishi Markandeshwar Deemed to be University, Mullana, Ambala, Haryana, India

Correspondence Address:
Inderjeet Verma
MM College of Pharmacy, Maharishi Markandeshwar Deemed to be University, Mullana, Ambala- 133207, Haryana
India

Background: Cystatin C is a non-glycosylated basic protein that is produced and secreted at a constant rate by all nucleated cells. Cystatin C is a more reliable marker than the serum creatinine because it is less affected by external factors such as gender, race and muscle mass. However, the comparison of serum cystatin C level in type 2 diabetes mellitus is not well known in people with obesity. Objectives: To estimate the level of cystatin C in type 2 diabetes and that can be explained by the change in obesity. Thus, this current study aimed to determine and compare the level of cystatin C in type 2 DM with obesity and also correlate the cystatin C level with the quality of life in type 2 DM and obesity. Material and Methods: We have taken three groups: Group A containing type 2 DM, Group B containing obesity, and Group C containing type 2 DM with obesity. In all, 25 patients in each group were selected and analyzed for cystatin C. Results: Cystatin C level was very high in type 2 DM with obesity group. The P value was 0.008 in type 2 DM with the obesity group and it has shown a highly significant correlation with BMI. In our study, we have also seen the positive correlation of cystatin C with BMI in Group B plain obese and Group C diabetes obese than Group A diabetes non-obese. We have seen in our study and found a poor correlation between HbA1c, RBS and cystatin C. Conclusion: The level of cystatin C is much higher in type 2 DM with obese patient as compared with type 2 DM and obese patients.


How to cite this article:
Jhatta C, Girdhar J, Gupta S, Verma I. To compare the level of cystatin C in type 2 diabetes mellitus with obesity.Indian J Endocr Metab 2020;24:312-318


How to cite this URL:
Jhatta C, Girdhar J, Gupta S, Verma I. To compare the level of cystatin C in type 2 diabetes mellitus with obesity. Indian J Endocr Metab [serial online] 2020 [cited 2020 Sep 23 ];24:312-318
Available from: http://www.ijem.in/article.asp?issn=2230-8210;year=2020;volume=24;issue=4;spage=312;epage=318;aulast=Jhatta;type=0