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  Indian J Med Microbiol
 

Figure 1: A schematic representation of hormonal control of pubertal development. Kisspeptin from Kiss neurons stimulates GnRH secretion by a direct effect on GnRH neurons. KiSS-1 neurons in the ARC appear to be involved in the negative feedback regulation of GnRH/LH by sex steroids. The expression of KiSS-1 mRNA in the arcuate is inhibited by estradiol (E), and testosterone (T). + = stimulation, – = inhibition

Figure 1: A schematic representation of hormonal control of pubertal development. Kisspeptin from Kiss neurons stimulates GnRH secretion by a direct effect on GnRH neurons. KiSS-1 neurons in the ARC appear to be involved in the negative feedback regulation of GnRH/LH by sex steroids. The expression of KiSS-1 mRNA in the arcuate is inhibited by estradiol (E), and testosterone (T). + = stimulation, – = inhibition