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  Indian J Med Microbiol
 

Figure 1: Models of thioredoxin-interacting protein action: (a) Role of thioredoxin-interacting protein in the thioredoxin system. Thioredoxin-interacting protein binds and inhibits the reduced form of thioredoxin, thereby functioning as a rheostat that modulates both redox status and reactive oxygen species-mediated signaling to regulate metabolism and other cellular processes. (b) Proposed role of thioredoxin-interacting protein in type 2 diabetes. Chronic glucose load on the pancreas, triggering thioredoxin-interacting protein-mediated β cell failure and overt diabetes. Adapted with permission from[1]

Figure 1: Models of thioredoxin-interacting protein action: (a) Role of thioredoxin-interacting protein in the thioredoxin system. Thioredoxin-interacting protein binds and inhibits the reduced form of thioredoxin, thereby functioning as a rheostat that modulates both redox status and reactive oxygen species-mediated signaling to regulate metabolism and other cellular processes. (b) Proposed role of thioredoxin-interacting protein in type 2 diabetes. Chronic glucose load on the pancreas, triggering thioredoxin-interacting protein-mediated β cell failure and overt diabetes. Adapted with permission from<sup>[1]</sup>