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Year : 1997  |  Volume : 1  |  Issue : 1  |  Page : 27-31

Genome Mapping

Correspondence Address:
A. J Rachel

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Source of Support: None, Conflict of Interest: None

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In the last few years there have been rapid advances in developing genetic maps for humans, greatly enhancing our ability to localize and identify genes for inherited disorders. A multipronged collaborative approach has been adopted to map the human genome. A combination of physical and genetic mapping strategies together with computer algorithms will decide on the maximum likelihood of odds for position of genes and resolve the ultimate order. A physical map of the human genome containing 15,086 STSs with an average spacing of 199 kb has been constructed. A radiation hybrid map anchor map. This information was combined with the results of STS content screening of 10, 850 loci against a YAC library to produce an integrated map. More than 3235 expressed sequences were also localized to the above map. This provides a resource for ready transference to physical maps and achieving one of the goals of the human genome project – a comprehensive high density genetic map. Gene mapping studies also provide evolutionary information which will provide clues about adaptive nurtinale underlying genome organization. Significant maps of twenty eight mammalian species have been made. Advances in medical genetics including mapping of human genome, improved therapy for genetic disorders and new test for carrier detection and prenatal diagnosis have created a growing demand for clinical genetic services. Extensive gene mapping should be able to further such services like diagnosis, management and genetic counseling more effectively and extensively.

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