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Year : 1997  |  Volume : 1  |  Issue : 1  |  Page : 3-7

Endocrine Profile Of Patients With Uterine Cervical Carcinoma

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J. M Bhatavdekar

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Most human cervical neoplasms are squamous cell carcinomas, which are believed to be hormone dependent. We investigated the role of peptide and steroid hormones in 54 pre-menopausal and 15 post-menopausal women with uterine cervical carcinoma. Circulating FSH, LH, prolactin (PRL), estradiol (E2), progesterone (Pg) and testosterone (T) were estimated. The control group comprised 15 pre-menopausal and 15 post-menopausal healthy, age matched women. In the premeno pausal group, women with cervical cancer had higher levels of FSH (p<0.001), LH (p<0.05) with lower levels of E2 (p< 0.001) and T (p<0.02) than controls. When grouped accorded to disease stage, early stage patients had higher levels of LH (p<0.01) and T (p<0.01) than controls. In addition, there was a trend to higher levels of E2 and Pg. These findings suggest that hormonal imbalance may play a leading role in the pathogenesis of uterine cervical carcinoma; it may precede initiate or accelerate the development of these tumours.

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