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Year : 2004  |  Volume : 6  |  Issue : 1  |  Page : 9-14

Prevalence Of Glucose Intolerance Among Adolscent And Young Women With Polycystic Ovary Syndrome In India

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Ganie M Ashraf

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The study was carried out to estimate the prevalence of glucose intolerance and insulin sensitivity in adolescents and young women with polycystic ovary syndrome (PCOS). One hundred sixty eight young women who attended our Endocrine Clinic for hirsutism and/or oligo-menorrhea were enrolled for the study. National Institute Of Child Health and Human Development 1990 consensus criteria were used for diagnosis of PCOS. Oral glucose tolerance test (OGTT) was done to study the glucose intolerance and insulin sensitivity parameters. Analaysis of plasma glucose was done before and, 60 and 120 minutes after 75 gm of oral glucose challenge. Insulin sensitivity was calculated based on fasting insulin levels in all subjects. The degree of glucose intolerance and insulin resistance was correlated with severity of hyperandrogenism, body mass index (BMI), and family history of diabetes mellitus. Results indicate higher incidence of glucose intolerance even at younger age in PCOS females. Thirty six percent of PCOS women had impaired glucose tolerance and 9% had diabetes mellitus with WHO 1999 criteria. With the application of ADA 1997 criteria, we observed impaired fasting glucose in 15% and diabetes mellitus in 3% of patients. Higher BMI and hyperandrogenism was directly correlated with the severity of glucose intolerance. Family history of known diabetes was present in 42.8 % subjects and when correlated with OGTT abnormality, it showed no significant correlation, although a rising trend was seen in plasma glucose and plasma insulin levels in subjects with family history of diabetes mellitus in first and second-degree relatives. We conclude that glucose intolerance and insulin resistance is common in Indian PCOS women and its poor correlation with rampant diabetes mellitus in he general population may indicate early modification of lifestyle factors by those with positive family history.

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