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Table of Contents
Year : 2011  |  Volume : 15  |  Issue : 5  |  Page : 70-71

Outbreak of Escherichia coli and diabetes mellitus

Wiwanitkit House, Bangkhae, Bangkok - 10160, Thailand

Date of Web Publication20-Jul-2011

Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok - 10160
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.83050

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How to cite this article:
Wiwanitkit V. Outbreak of Escherichia coli and diabetes mellitus. Indian J Endocr Metab 2011;15, Suppl S1:70-1

How to cite this URL:
Wiwanitkit V. Outbreak of Escherichia coli and diabetes mellitus. Indian J Endocr Metab [serial online] 2011 [cited 2021 Feb 28];15, Suppl S1:70-1. Available from: https://www.ijem.in/text.asp?2011/15/5/70/83050


The present global public health issue on the outbreak of  Escherichia More Details coli is the world's focus. The infection started in Germany and spread widely in Europe. [1] The pathogenic E. coli infection can cause severe diarrhea as well as other more serious presentations. In some severe cases, infected with E. coli, O157: H7, renal complications such as hemolytic uremic (HUS) syndrome can be expected.

HUS is known for its relationship with diabetes mellitus. Due to pancreatic injury, [2] the increased incidence of insulin-dependent diabetes mellitus in pediatric patients infected with O157: H7 E. coli is reported. [1],[3] It usually accompanies renal failure, which is a complication of HUS. [1],[2],[3],[4],[5] Suri et al. mentioned that "Survivors with diarrhea-associated HUS have a significantly increased incidence of diabetes due to complete insulin deficiency, which may recur several years after the initial infection." [1] As a conclusion, Suri et al. proposed following up for diabetes among the affected patients during acute illness and in long term after severe infection. [4]

In addition to the copresentation with HUS, E. coli is also reported for its relationship to development of peritonitis in diabetic patients. In an animal model study, it is proved that endothelin-1 played important role in development of peritonitis, and increased plasma endothelin-1 concentrations was common in E. coli septic peritonitis. [6]

In conclusion, a certain relationship between diabetes mellitus and E. coli infection is evidenced. In the present E. coli outbreak, the importance of diabetes mellitus, as a possible comorbidity, should not be forgotten.

   References Top

1.Suri RS, Mahon JL, Clark WF, Moist LM, Salvadori M, Garg AX. Relationship between Escherichia coli O157:H7 and diabetes mellitus. Kidney Int Suppl 2009;112:S44-6.  Back to cited text no. 1
2.Robitaille P, Gonthier M, Grignon A, Russo P. Pancreatic injury in the hemolytic-uremic syndrome. Pediatr Nephrol 1997;11:631-2.  Back to cited text no. 2
3.al Herbish AS, al Rasheed SA. Persistent insulin-dependent diabetes mellitus in hemolytic uremic syndrome. Child Nephrol Urol 1992;12:59-61.  Back to cited text no. 3
4.Suri RS, Clark WF, Barrowman N, Mahon JL, Thiessen-Philbrook HR, Rosas-Arellano MP, et al. Diabetes during diarrhea-associated hemolytic uremic syndrome: A systematic review and meta-analysis. Diabetes Care 2005;28:2556-62.  Back to cited text no. 4
5.Taylor CM, White RH, Winterborn MH, Rowe B. Haemolytic-uraemic syndrome: Clinical experience of an outbreak in the West Midlands. Br Med J (Clin Res Ed) 1986;292:1513-6.  Back to cited text no. 5
6.Tsukada K, Katoh H, Shiojima M, Suzuki T, Takenoshita S, Nagamachi Y. Increased plasma endothelin-1 concentrations in E. coli septic peritonitis rats with diabetes mellitus. Exp Clin Endocrinol 1993;101:315-8.  Back to cited text no. 6

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