Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Advertise | Login 
Search Article 
Advanced search 
  Users Online: 2332 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  
Year : 2011  |  Volume : 15  |  Issue : 7  |  Page : 233-237

Hypothalamic pituitary dysfunction in acute nonmycobacterial infections of central nervous system

1 Department of Medicine, Maulana Azad Medical College, New Delhi, India
2 Department of Biochemistry, Maulana Azad Medical College, New Delhi, India

Correspondence Address:
Dinesh K Dhanwal
Department of Medicine, Maulana Azad Medical College, Bahadur Zafar Marg, New Delhi - 10 002
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.84873

Rights and Permissions

Background and Objective: Acute and chronic central nervous system (CNS) infections are not uncommon in tropical countries and are associated with high morbidity and mortality if specific targeted therapy is not instituted in time. Effects of tubercular meningitis, a form of chronic meningitis on hypothalamic pituitary axis, are well known both at the time of diagnosis and after few months to years of illness. However, there are few reports of pituitary dysfunction in subjects with acute CNS infections. Therefore, this study was aimed at evaluating the pituitary hormonal profile in patients with nonmycobacterial acute meningitis at the time of presentation. Materials and Methods: This prospective case series study included 30 untreated adult patients with acute meningitis, meningoencephalitis, or encephalitis, due to various nonmycobacterial agents, admitted and registered with Lok Nayak Hospital, Maulana Aazd Medical College, New Delhi, between September 2007 and March 2009. Patients with preexisting endocrine diseases, tubercular meningitis and patients on steroids were carefully excluded from the study. The basal pituitary hormonal profile was measured by the electrochemilumniscence technique for serum cortisol, luetinizing hormone (LH), follicular stimulating hormone (FSH), prolactin (PRL), thyrotropin (TSH), free tri-iodothyronine (fT3), and free thyroxine (fT4). Results: The cases (n = 30) comprised of patients with acute pyogenic meningitis (n = 23), viral meningoencephalitis (n = 4), brain abscess (n = 2), and cryptococcal meningitis (n = 1). The mean age of patients was 28.97 ± 11.306 years. Out of 30 patients, 14 (46.7%) were males and 16 (58.1%) were females. Adrenal insufficiency both absolute and relative was seen in seven (23.3%) and hyperprolactinemia was seen in nine (30.0%) of the patients. One study subject had central hypothyroidism and seven (23.3) showed low levels of LH and/or FSH. None of patients showed clinical features suggestive of central diabetes insipidus. Conclusion: Acute infections of the CNS are associated with abnormalities in the pituitary hormone profile. Further studies are required to evaluate the hypothalamic pituitary axis using dynamic tests and imaging by MRI.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded371    
    Comments [Add]    
    Cited by others 3    

Recommend this journal