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Year : 2012  |  Volume : 16  |  Issue : 1  |  Page : 136-138

Body fat distribution in women with familial partial lipodystrophy caused by mutation in the lamin A/C gene

1 Department of Medicine, Divisions of Endocrinology and Metabolism, Ribeirão Preto Medical School, São Paulo University, Brazil
2 Department of Community Health, Service of Endocrinology and Diabetes, University Hospital Walter Cantídio, Fortaleza Medical School, Ceará University, Brazil

Correspondence Address:
Luciana Z Monteiro
Department of Medicine, Ribeirão Preto Medical School, São Paulo University of São Paulo, Av. Bandeirantes, 3900, Monte Alegre, Ribeirão Preto (SP), 14049-900
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.91209

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Familial partial lipodystrophy (FPLD), Dunnigan variety, is an autosomal dominant disorder caused due to missense mutations in the lamin A/C (LMNA) gene encoding nuclear lamina proteins. Patients with FPLD are predisposed to metabolic complications of insulin resistance such as diabetes. We sought to evaluate and compare body fat distribution with dual-emission X-ray absorptiometry in women with and without FPLD and identify densitometric, clinical and metabolic features.

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