Ovarian granulosa cell tumor: An uncommon presentation with primary amenorrhea and virilization in a pubertal girl

Sunil Kumar Kota; Kotni Gayatri; Jaya Prakash Pani; Lalit Kumar Meher; Siva Krishna Kota; Kirtikumar D Modi

doi:10.4103/2230-8210.100658

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CASE REPORT

Year : 2012 | Volume : 16 | Issue : 5 | Page : 836-839

Ovarian granulosa cell tumor: An uncommon presentation with primary amenorrhea and virilization in a pubertal girl

Sunil Kumar Kota¹, Kotni Gayatri², Jaya Prakash Pani³, Lalit Kumar Meher⁴, Siva Krishna Kota⁵, Kirtikumar D Modi¹
¹ Department of Endocrinology, Medwin Hospital, Hyderabad, Andhra Pradesh, India
² Department of Obstetrics and Gynecology, Riyadh Care Hospital, Riyadh, Saudi Arabia
³ Department of Obstetrics and Gynecology, Apollo Hospital, Bhubaneswar, Orissa, India
⁴ Department of Medicine, MKCG Medical College, Berhampur, Orissa, India
⁵ Department of Anesthesia, Central Security Hospital, Riyadh, Saudi Arabia

Correspondence Address:
Sunil Kumar Kota
Department of Endocrinology, Medwin Hospital, Chiragh Ali Lane, Nampally, Hyderabad - 500 001, Andhra Pradesh
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/2230-8210.100658

A 16-year-old girl presented with primary amenorrhea and excess hair growth on her body and face for the last three years, along with pain and a mass in her lower abdomen for last one year. Examination revealed hirsutism and other virilizing features, with an irregular mass in the lower abdomen corresponding to 16 weeks'gestation. Serum testosterone was 320 ng / dl and ultrasonogram of the pelvis revealed a solid mass of 5 × 4 cm in the left adnexa. Suspecting it to be a virilizing tumor of the left ovary, the patient was subjected to staging laparotomy, which revealed stage 1a ovarian involvement amenable to surgical resection alone. Histopathological examination confirmed the diagnosis of granulosa cell tumor of the ovary. Postoperatively the serum testosterone returned to 40 ng / dl and her menstrual cycle started after two months of surgery.

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