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Year : 2012  |  Volume : 16  |  Issue : 5  |  Page : 846-849

Combined granulomatous and lymphocytic hypophysitis presenting as pituitary incidentaloma in a middle-aged woman

1 Department of Endocrinology, Army Hospital (Research and Referral), Delhi Cantt, India
2 Department of Pathology, Army Hospital (Research and Referral), Delhi Cantt, India
3 Department of Neurosurgery, Army Hospital (Research and Referral), Delhi Cantt, India

Correspondence Address:
M K Garg
Department of Endocrinology, Army Hospital (Research and Referral), Delhi Cantt-10
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.100680

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We report a case of 41-year-old lady who presented with chronic headache of 6-month duration and a sellar mass with a suprasellar extension on imaging, which was interpreted as pituitary macroadenoma. She had normal pituitary function and visual perimetry. On clinical examination and imaging it was provisionally diagnosed as pituitary incidentaloma due to hypophysitis and she was advised steroid therapy, but underwent transnasal resection of the tumor against suggestion. Histopathological examination revealed combined granulomatous and lymphocytic hypophysitis most likely of autoimmune in origin. Definitive diagnosis of hypophysitis can be made only on histopathological examination. As most cases of autoimmune hypophysitis are surgically treated, patients should be assessed on individual basis for requirement of steroids in postoperative period.

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