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Year : 2012  |  Volume : 16  |  Issue : 5  |  Page : 853-855

Hypokalemic paralysis as a presenting manifestation of primary Sjögren's syndrome: A report of two cases

1 Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India
2 Department of Clinical Immunology and Rheumatology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Rajesh Khadgawat
Associate Professor, Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110029
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.100684

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Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by a progressive lymphocytic infiltration of the exocrine glands with varying degrees of systemic involvement. Overt or latent renal tubular acidosis (RTA), caused by tubulointerstitial nephropathy, is a common extraglandular manifestation of pSS. Hypokalemic paralysis is a well known, albeit rare complication of severe distal RTA from any cause. Cases of pSS manifesting for the first time as hypokalemic paralysis caused by distal RTA have been rarely reported. We herein present our experience of two cases, who presented to us for evaluation of hypokalemic paralysis and on work up found evidence of distal RTA, which on further work up found to be secondary to pSS. A high index of suspicion for pSS should be kept in all patients with hypokalemic paralysis.

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