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MINI REVIEW
Year : 2012  |  Volume : 16  |  Issue : 8  |  Page : 178-184

The variability of responses to growth hormone therapy in children with short stature


1 Department of pediatric endocrinology William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, London, United Kingdom
2 Department of Clinical and Experimental Medicine, Division of Pediatrics, Faculty of Health Sciences, Linköping University, SE-58185 Linköping, Sweden

Correspondence Address:
Martin O Savage
Department of Endocrinology, Barts and The London School of Medicine & Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ
United Kingdom
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Source of Support: Peter Bang has received honoraria from Ipsen, Merck-Serono, Pfizer and Novo Nordisk and grant support from Ipsen, Novo Nordisk and Sanofi-Aventis. Martin Savage has received honoraria from Ipsen, Pfizer, and Merck Serono, Conflict of Interest: None


DOI: 10.4103/2230-8210.104034

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Growth hormone (GH) is widely prescribed for children with short stature across a range of growth disorders. We describe the variability of responses seen in conditions approved for GH therapy. Although responses in different growth disorders are satisfactory, evidence is increasing for an unacceptably high rate of poor or unsatisfactory response (i.e., not leading to significant catch-up growth) in terms of change in height standard deviation score and height velocity. Consequently, there is a need to define a poor response and to prevent or correct it by optimizing treatment regimens. This review discusses the optimal investigation of the child who is a candidate for GH therapy so that a diagnosis-based guide to therapy and dosage can be made. The relevant parameters in the evaluation of growth response are described together with the definitions of a poor response.


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