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Year : 2012  |  Volume : 16  |  Issue : 8  |  Page : 288-290

Rathke's cyst with ectopic neurohypophysis presenting as severe short stature with delayed puberty

Department of Endocrinology & Metabolism, IPGMER & SSKM Hospital, Kolkata, India

Correspondence Address:
Deep Dutta
Department of Endocrinology & Metabolism, Room-9, 4th Floor, Ronald Ross Building, IPGMER & SSKM Hospital, Kolkata - 700 020, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.104062

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Ectopic neurohypophysis (EN) is found in nearly half of children with growth hormone deficiency (GHD). Rathke's cyst (RC) is uncommon in children and when present, hypopituitarism is found in nearly half of them. We present a fourteen and half-year-old girl with severe short stature and delayed puberty who on evaluation was found to have GHD, secondary hypocortisolism, and hypogonadism. Imaging revealed hypoplastic anterior pituitary, stalk agenesis, EN at tuber cinereum and intrapituitary RC. This is perhaps the first report of simultaneous occurrence of EN and RC, which was seen in a girl with multiple pituitary hormone deficiency. A primary defect in pituitary development may explain this simultaneous occurrence of EN and RC and hence this severe anterior pituitary function deficit.

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