Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Advertise | Login 
 
Search Article 
  
Advanced search 
  Users Online: 453 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  

 
Table of Contents
BRIEF COMMUNICATION
Year : 2012  |  Volume : 16  |  Issue : 8  |  Page : 302-303

Tuberous Sclerosis: An uncommon cause of hyperprolactinemia


1 Department of Endocrinology, Medwin hospital, Hyderabad, India
2 Department of Medicine, MKCG Medical College, Berhampur, Orissa, India

Date of Web Publication4-Jan-2013

Correspondence Address:
Sunil Kumar Kota
DNB Resident, Department of Endocrinology, Medwin Hospitals, Chiragh Ali Lane, Nampally Hyderabad-500001, Andhra Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.104068

Rights and Permissions
   Abstract 

Tuberous Sclerosis is a multi system genetic disorder affecting skin, central nervous system,kidney,heart and lungs. We present a case report of a 26 year old female with tuberous sclerosis who presented with galactorrhea and menstrual irregularities due to hyperprolactinemia.

Keywords: Tuberous sclerosis, hyperprolactinemia, galactorrhoea


How to cite this article:
Kota SK, Meher LK, Krishna S, Modi K D. Tuberous Sclerosis: An uncommon cause of hyperprolactinemia. Indian J Endocr Metab 2012;16, Suppl S2:302-3

How to cite this URL:
Kota SK, Meher LK, Krishna S, Modi K D. Tuberous Sclerosis: An uncommon cause of hyperprolactinemia. Indian J Endocr Metab [serial online] 2012 [cited 2020 Nov 25];16, Suppl S2:302-3. Available from: https://www.ijem.in/text.asp?2012/16/8/302/104068


   Introduction Top


Tuberous sclerosis (TSC) is a multi system genetic disorder affecting skin, brain/nervous system, kidneys, heart and lung and leading to growth of non malignant tumors. A combination of symptoms may include seizures, developmental delay, behavioral problems, skin abnormalities, lung and kidney disease. Tuberous sclerosis lesions infrequently cause symptoms in the endocrine, gastrointestinal (GI), and lymphatic systems. We hereby report a case of tuberous sclerosis presenting with hyperprolactinemia.


   Case Report Top


A 26-year-old female presented with galactorrhea for the past 10 days and menstrual irregularities over the past six months. Galactorrhea was spontaneous. Her last childbirth four years ago was uneventful. She had no head ache, vomiting, and visual impairment. She denied any history of substance abuse, drug intake (antipsychotic, anti emetic, hormonal preparations), hypothyroidism, chronic liver or kidney diseases, epilepsy. There was no significant family history. She was a well nourished female with mild pallor, tiny nodule on face, subungual fibroma in hands. There was spontaneous galactorrhea and mildly tender breasts without any signs of inflammation. Systemic examination was entirely normal with normal IQ. Ophthalmologic evaluation revealed white disk shaped retinal hamartoma. Routine laboratory investigations including renal and liver function tests, thyroid profile were normal. Serum prolactin was 85 ng/mL with FSH-4.66 and LH- 4.21 mIU/ml. In view of the theoretical possibility of involvement of cell groups of other anterior pituitary lineage, tests for evaluation of other anterior pituitary hormones were carried out and were found to be normal. Abdominal and pelvic ultrasound revealed no abnormality. Chest X-ray showed bilateral interstitial infiltrates. Echocardiogram of heart was normal. Computed tomography (CT) scan revealed multiple intracerebral calcifications. These calcified lesions/subependymal hamartomas are seen along the lateral surface of the lateral ventricles giving rise to characteristic candle dripping appearance. Magnetic resonance imaging (MRI) of the brain ruled out the presence of any pituitary mass. The combined clinical scenario along with the radiologic findings leads to the diagnosis of TSC with hyperprolactinemia. Patient was prescribed cabergoline 0.5 mg twice daily, which resulted in amelioration of galactorrhea and regularization of menses.


   Discussion Top


There is a growing body of evidence that TSC patients develop hormone secreting tumors involving the neuroendocrine system at higher frequency than the general population. Cushing's disease, [1] hypoglycemia secondary to insulinomas, [2] precocious puberty, thyrotoxicosis, hypercalcemia secondary to parathyroid adenomas, [3] hyperprolactinemia [4] and acromegaly have all been reported in TSC patients. The circulating prolactin of our patient may be of pituitary origin or may possibly be secreted ectopically by a hamartoma. There has been evidence linking neuroendocrine tumors to the AKT/mTOR/S6 kinase pathway that is regulated by the hamartin/tuberin (TSC1/TSC2) complex. Thus, it is beginning to appear that the occurrence of these neuroendocrine tumors (NET) in TSC is more than random coincidence.

 
   References Top

1.Nandagopal R, Vortmeyer A, Oldfield EH, Keil MF, Stratakis CA. Cushing's syndrome due to a pituitary corticotropinoma in a child with tuberous sclerosis: an association or a coincidence? Clin. Endocrinol (Oxf) 2007;67:639-41.  Back to cited text no. 1
[PUBMED]    
2.Eledrisi MS, Stuart CA, Alshanti M. Insulinoma in a patient with tuberous sclerosis: Is there an association? EndocrPract 2002;8:109-12.  Back to cited text no. 2
[PUBMED]    
3.Mortensen LS, Rungby J. Tuberous sclerosis and parathyroid adenoma. J ClinPathol 1991;44:961-2.  Back to cited text no. 3
[PUBMED]    
4.Bloomgarden ZT, McLean GW, Rabin D. Autonomous hyperprolactinemia in tuberous sclerosis. Arch Intern Med 1981;141:1513-5.  Back to cited text no. 4
[PUBMED]    




 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
   Case Report
   Discussion
    References

 Article Access Statistics
    Viewed798    
    Printed21    
    Emailed0    
    PDF Downloaded136    
    Comments [Add]    

Recommend this journal