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Year : 2012  |  Volume : 16  |  Issue : 8  |  Page : 356-357

Reassessment of elicitation of myoedema in evaluation of overt hypothyroidism: A pilot study

Department of Endocrinology, JIPMER, Puducherry, India

Correspondence Address:
Karthik Balachandran
Department of Endocrinology, 557, Fourth Floor, Inpatient Division, Superspecialty Block, Dhanvantri Nagar, JIPMER, Puducherry-605 006
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.104091

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Introduction: There is a need to reassess the significance of myoedema in evaluation of overt hypothyroidism in the current day clinical practice. It is commonly checked for by flicking across the biceps belly expecting a transient mound at the points of tactile stimuli with mild pressure. Aim and Objective: To assess elicitation of myoedema in overt hypothyroidism (defined arbitrarily as TSH >50 mIU/L in primary hypothyroidism and fT4 <0.6 ng/dl in secondary hypothyroidism). Results: The 28 primary overt hypothyroid (OH) patients were divided into three groups as mild, moderate, and severe depending on TSH levels as those with 50-100, 100-150, and >150 mIU/L. Myoedema was elicited in 8 of 13 in the severe OH group, in 2 of 7 in moderate OH group and in 1 of 8 in the mild OH group. In the group of secondary hypothyroidism, myoedema was elicitable in one of two patients. The odds ratio for presence of both myoedema and clinical features of myopathy in a group of overt hypothyroid patients with TSH >150 mIU/L as compared to <150 mIU/L was 17.5. Similarly, the odds ratio for the presence of only myoedema was 6.4 while the odds ratio for presence of only clinical features of myopathy was 3.67. While the odds ratios involving presence of myoedema neared statistical significance, that with the presence of clinical features of myopathy alone did not. Conclusion: Examination for eliciting myoedema is useful when evaluating a case of overt hypothyroidism.

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