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BRIEF COMMUNICATION
Year : 2012  |  Volume : 16  |  Issue : 8  |  Page : 373-375

Adrenocortical carcinoma: An extremely uncommon entity and the role of Immunohistochemistry in its diagnosis


1 Department of Pathology, Assam Medical College and Hospital, Dibrugarh, India
2 Consultant Endocrinologist, Excel Center, Ulubari, Guwahati, India
3 Department of Radiology and Assam Medical College and Hospital, Dibrugarh, Assam, India

Correspondence Address:
Manash P Baruah
Excel Center, Barthakur Mill Road, Ulubari, Guwahati - 781 007
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.104098

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Adrenocortcal carcinoma is an extremely uncommon entity with an incidence of two in one millionth population. Here we present a 60 year gentleman with pain in abdomen, nausea, and backache, and weight loss. Contrast enhanced computed tomography (CECT) abdomen revealed a heterogenous well defined mass measuring (15 × 10.3 × 13) cm 3 on the left suprarenal region with central necrosis which extended medially up to the midline. Locally, the growth infiltrated the upper pole of left kidney. Initially, the differential diagnosis included that of renal cell carcinoma arising from upper pole of left kidney involving adrenal gland. The patient underwent left radical nephrectomy and left adrenalectomy. Histological evaluation could not differentiate it from of malignant pheochromocytoma, but immunohistochemistry confirmed it as adrenocortical carcinoma. This case highlights the crucial role of immunohistochemistry in establishing the diagnosis like tumors.


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