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BRIEF COMMUNICATION
Year : 2012  |  Volume : 16  |  Issue : 8  |  Page : 393-395

Cardiovascular disease risk in young women with polycystic ovary syndrome


1 Department of Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
2 Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Correspondence Address:
P Dabadhgao
Department of Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.104105

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Introduction: Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age group. Insulin resistance and the consequent hyperinsulinemia seem to be the central pathophysiological mechanism that links PCOS to its associated metabolic derangements. Women with PCOS exhibit a number of risk factors for coronary artery disease. We studied risk of CVD using two surrogate markers, carotid intima-media thickness (CIMT) and brachial artery flow-mediated dilation (FMD). Aims and objectives: To study cardiovascular disease risk in young women (18-35 years age) with PCOS using CIMT and FMD. Materials and Methods: Sixty women with PCOS (age: 23.8 ± 4.5 years; body mass index [BMI]: 23.5 ± 4.2 kg/m 2 ) were compared with 30 age- and BMI-matched healthy controls (age: 26.3 ± 5.4 years; BMI: 22.6 ± 3.8 kg/m 2 ). Diagnosis of PCOS was made using the Rotterdam criteria. Fasting blood sample was analyzed for glucose, insulin, lipid profile, high sensitivity C-reactive protein (hsCRP), high molecular weight adiponectin (HMWADP), and interleukin 6 (IL6). CIMT and FMD were performed. Results: PCOS patients had a higher waist to hip ratio (W/H) [0.86 ± .07 vs. 0.80 ± .05] and free testosterone index (FTI) [6.6 ± 6.5 vs. 2.0 ± 1.0] in comparison to controls. There was no difference in the two groups in lipid profile parameters and HOMA IR. CIMT was significantly higher (0.59 ± .1 mm vs. 0.50 ± .05 mm, P value <.001) and FMD lower (10.3 ± 3.9% vs. 15.2 ± 5.5%, P value < .001) in cases when compared to controls. FMD negatively correlated with W/H ratio (r: -0.257) and hsCRP (r: -0.347), while IMT showed positive correlation with IL6 (r: 0.325) and hsCRP (r: 0.303) and a negative correlation with high-density lipoprotein (HDL) [r: -0.224], all P values < .05. Conclusions: Patients with PCOS have evidence for increased CVD risk as shown by endothelial dysfunction manifested by increased CIMT and a lower FMD.


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