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BRIEF COMMUNICATION
Year : 2013  |  Volume : 17  |  Issue : 3  |  Page : 446-450

Transcriptomic analysis of visceral adipose from healthy and diabetic obese subjects


1 Department of Endocrinology, S.M.S. Medical College, Jaipur, Rajasthan, India
2 National Research Center on Plant Biotechnology, Indian Agricultural Research Institute, Pusa, India
3 Department of Pharmacology, S.M.S. Medical College, Jaipur, Rajasthan, India
4 Department of Physiology, S.M.S. Medical College, Jaipur, Rajasthan, India
5 Invitrogen BioServices India Pvt. Ltd., Gurgaon, Haryana, India
6 Functional Genomic Unit, CSIR-Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, New Delhi, India

Correspondence Address:
Sandeep Kumar Mathur
D-116, Shivadarea, Bapunagar Jaipur, Rajasthan
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.111639

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Understanding the role of visceral fat accumulation in the occurrence and progression of metabolic syndrome is of considerable interest. In order to understand the difference between visceral tissue biology of healthy and unhealthy obese individuals, we have used microarray profiling to compare genome-wide expression differences between visceral adipose tissue biopsies obtained from obese diabetics, and those from age and body mass index (BMI) matched normal glucose tolerance subjects. Whereas genes upregulated in diabetics showed enrichment of natural killer cell mediated cytotoxicity, the downregulated genes showed enrichment of biosynthesis of unsaturated fatty acids. Given the known inhibitory effect of unsaturated fatty acids on inflammation and natural killer cell number or activity, our results suggest that visceral inflammation resulting from decreased levels of unsaturated fatty acids may underlie progression of diabetes in obese individuals.


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