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Year : 2013  |  Volume : 17  |  Issue : 3  |  Page : 505-508

Gonadal dysgenesis and the Mayer-Rokitansky-Kuster-Hauser Syndrome in a girl with a 46, XX karyotype: A case report and review of literature

1 Department of Obstetrics and Gynecology, HediChaker Hospital, 3029 Sfax, Tunisia
2 Department of Endocrinology, HediChaker Hospital, 3029 Sfax, Tunisia

Correspondence Address:
Mahdi Kamoun
Department Endocrinology, HediChaker Hospital, Magida Boulila Avenue, 3029 Sfax
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.111663

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Mayer-Rokitansky-Kuster-Hauser (MRKH) is a characteristic syndrome in which the Mullerian structures are absent or rudimentary. It is also associated with anomalies of the genitourinary and skeletal systems. Its association with gonadal dysgenesis is extremely rare and appears to be fortuitous, independent of chromosomal anomalies. We report such a case in a 21-year-old girl who presented primary amenorrhea and impuberism. The endocrine study revealed hypergonadotrophic hypogonadism. The karyotype was normal, 46, XX. No chromosome Y was detected at the fluorescence in situ hybridization (FISH) analysis. Internal genitalia could not be identified on the pelvic ultrasound and pelvic magnetic resonance imaging. Laparoscopy disclosed concomitant ovarian dysgenesis and MRKH syndrome. There were no other associated malformations. Hormonal substitution therapy with oral conjugated estrogens was begun. The patient has been under regular follow-up for the last two years and is doing well.

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