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Year : 2013  |  Volume : 17  |  Issue : 5  |  Page : 851-854

Progression of puberty after initiation of androgen therapy in patients with idiopathic hypogonadotropic hypogonadism

Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Delhi, India

Correspondence Address:
Ariachery Ammini
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.117245

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Background: Onset of puberty in boys usually occurs by 14 years of age. Some boys may exhibit delayed sexual maturation till about 17-18 years of age. However, pubertal onset beyond 18 years of age is exceedingly rare. Materials and Methods: Patients diagnosed as idiopathic hypogonadotropic hypogonadism (IHH) who had onset of puberty (increase in testicular volume >10 ml) while on androgen therapy were studied. These patients were evaluated prospectively. Results: There were nine subjects that were included in the study. The pre-therapy testicular volumes ranged from 3 to 6 ml. Luteinizing hormone (LH) levels increased from 1.2 ± 0.96 to 2.8 ± 1.0 IU/L, follicular stimulating hormone (FSH) levels increased from 1.5 ± 0.79 to 3.5 ± 1.9 IU/L, and testosterone increased from 0.36 ± 0.16 to 3.4 ± 2.1 ng/ml. Three out of nine patients had testosterone levels below 3 ng/ml. Conclusion: Our present study indicates that pubertal development can occur in patients presenting with hypogonadotropic hypogonadism after 18 years of age. However, acquired pubertal status may be subnormal

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