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Table of Contents
ORIGINAL ARTICLE
Year : 2013  |  Volume : 17  |  Issue : 8  |  Page : 435-436

Clinical experience with biphasic insulin aspart in people with type 2 diabetes: Results from the Libya cohort of the A 1 chieve study


1 Diabetic Centre, Benghazi, Libya
2 Alafia Clinic, Benghazi, Libya
3 Tripoli Medical Centre, Benghazi, Libya
4 Benghazi, Libya
5 Department of CMR, Novo Nordisk Pharma Gulf FZ-LLC, Dubai, United Arab Emirates
6 Department of Endocrinology Division and Medicine, Benghazi Medical Treatment, Benghazi, Libya

Date of Web Publication27-Nov-2013

Correspondence Address:
Praful N Chakkarwar
Novo Nordisk Pharma Gulf FZ-LLC, Dubai Healthcare City Building 64, Block A & B, P.O. Box 505052 Dubai
United Arab Emirates
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2230-8210.122062

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   Abstract 

Background: The A 1 chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care across four continents. Materials and Methods: Data was collected at baseline, at 12 weeks and at 24 weeks. This short communication presents the results for patients enrolled in biphasic insulin aspart sub group from Libya. Results: A total of 179 patients were enrolled in the biphasic insulin aspart subgroup. All the patients were prior insulin users. At baseline glycaemic control was poor (mean HbA 1 c: 9.3%). After 24 weeks of treatment there was an improvement in HbA 1 c (−0.9%). Hypoglycaemic events reduced from 7.2 events/patient-year to 3.7 events/patient-year in 24 weeks. SADRs did not occur in any of the study patients. Conclusion: Starting or switching to biphasic insulin aspart was associated with improvement in glycaemic control with a low rate of hypoglycaemia.

Keywords: A 1 chieve study, biphasic insulin aspart, Libya, type 2 diabetes mellitus


How to cite this article:
Hajjaji IM, Sherif I, Elazrag A, Jaber S, Chakkarwar PN, Eltabal S. Clinical experience with biphasic insulin aspart in people with type 2 diabetes: Results from the Libya cohort of the A 1 chieve study. Indian J Endocr Metab 2013;17, Suppl S2:435-6

How to cite this URL:
Hajjaji IM, Sherif I, Elazrag A, Jaber S, Chakkarwar PN, Eltabal S. Clinical experience with biphasic insulin aspart in people with type 2 diabetes: Results from the Libya cohort of the A 1 chieve study. Indian J Endocr Metab [serial online] 2013 [cited 2021 Jan 20];17, Suppl S2:435-6. Available from: https://www.ijem.in/text.asp?2013/17/8/435/122062


   Introduction Top


The incidence of diabetes in Libya is estimated to be 8.9%. [1] Fear of hypoglycaemia and gain in body weight are barriers for initiation of insulin therapy. [2] Modern insulin analogues are a convenient new approach or tool to glycaemic control, associated with low number of hypoglycaemia and favourable weight change. [3] A 1 chieve, a multinational, 24-week, non-interventional study, assessed the safety and effectiveness of insulin analogues in people with T2DM (n = 66,726) in routine clinical care. [4] This short communication presents the results for patients enrolled in biphasic insulin aspart sub group from Libya.


   Materials and Methods Top


Please refer to editorial titled: The A 1 chieve study: Mapping the Ibn Battuta trail. The study was started with an aim to collect data on all the insulin analogue viz insulin detemir, biphasic insulin aspart and insulin aspart. However, due to ongoing revolution, the complete data could not be collected. Here we present the data for biphasic insulin aspart subgroup.


   Results Top


A total of 316 patients were enrolled in the study. The majority of patients (189) were started on or were switched to Biphasic insulin aspart. Other groups were insulin detemir (n = 58), basal + insulin aspart (n = 44) and other insulin combinations (n = 25). Being the biggest treatment group, this communication describes the results for patients treated with insulin therapy before and then switched to biphasic insulin aspart.

The patient characteristics for biphasic insulin aspart subgroup are shown in the [Table 1]. Glycaemic control at baseline was poor in this population.
Table 1: Overall demographic data

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Safety data

179 patients started on biphasic insulin aspart ± OGLD, and all the patients were on insulin therapy prior to the study. After 24 weeks of switching to biphasic insulin aspart, hypoglycaemic events reduced from 7.2 events/patient-year to 3.7 events/patient-year [Table 2] and [Table 3].
Table 2: Overall safety data

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Table 3: Insulin dose

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Efficacy data

All parameters of glycaemic control improved from baseline to study end [Table 4].
Table 4: Overall efficacy data

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   Conclusion Top


Our study reports improved glycaemic control following 24 weeks of treatment with biphasic insulin aspart with or without OGLD. Hypoglycemic events decreased from baseline and SADRs did not occur in any of the study patients. A small increase in body weight was observed. Though the findings are limited by number of patients, still the trend indicates that biphasic insulin aspart can be considered effective and possess a safe profile for treating type 2 diabetes in Libya.

 
   References Top

1.IDF Diabetes Atlas. 5 th ed. 2011. Available from: http://www.idf.org/atlasmap/atlasmap [Last accessed on 2013 Jun 10].  Back to cited text no. 1
    
2.Korytkowski M. When oral agents fail: Practical barriers to starting insulin. Int J Obes Relat Metab Disord 2002;26 Suppl 3:S18-24.  Back to cited text no. 2
    
3.Hirsch IB. Insulin analogues. N Engl J Med 2005;352:174-83.  Back to cited text no. 3
    
4.Shah SN, Litwak L, Haddad J, Chakkarwar PN, Hajjaji I. The A 1 chieve study: A 60 000-person, global, prospective, observational study of basal, meal-time, and biphasic insulin analogs in daily clinical practice. Diabetes Res Clin Pract 2010;88 Suppl 1:S11-6.  Back to cited text no. 4
    



 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4]



 

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