| ORIGINAL ARTICLE |
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| Year : 2013 | Volume
: 17
| Issue : 8 | Page : 472-476 |
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Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Dubai cohort of the A 1 chieve study
Zain Gulzar1, Laxami Sharma2, Thomas Zachariya3
1 Department of Endocrinology, Mediclinic Dubai Mall Medical Center, Karama, Dubai, United Arab Emirates
2 Department of Endocrinology, Healers Medical Centre, Karama, Dubai, United Arab Emirates
3 Department of Endocrinology, Joseph Clinic, Karama, Dubai, United Arab Emirates
Correspondence Address:
Zain Gulzar
Mediclinic Dubai Mall Medical Center, Dubai
United Arab Emirates
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2230-8210.122084
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Background: The A 1 chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care across four continents. Materials and Methods: Data was collected at baseline, at 12 weeks and at 24 weeks.This short communication presents the results for patients enrolled from Dubai. Results: A total of 767 patients were enrolled in the study. Four different insulin analogue regimens were used in the study. Study patients had started on or were switched to biphasic insulin aspart (n = 231), insulin detemir (n = 369), insulin aspart (n = 29), basal insulin plus insulin aspart (n = 111) and other insulin combinations (n = 26). At baseline glycaemic control was poor for both insulin naïve (mean HbA 1 c: 9.2%) and insulin user (mean HbA 1 c: 9.1%) groups. After 24 weeks of treatment, both the groups showed improvement in HbA 1 c (insulin naïve: −1.9%, insulin users: −1.8%). SADRs did not occur in any of the study patients. Major hypoglycaemia was nil similar to that of baseline in insulin naïve group whereas major hypoglycaemic events reduced from 0.3 events/patient-year to 0.1 events/patient-year in insulin users. Conclusion: Starting or switching to insulin analogues was associated with improvements in glycaemic control with a low rate of hypoglycaemia. |
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